The Australian pair will meet for a second successive week as they headline the opening night's action of the PDC World Series of Darts' first visit to Brisbane, which will see 16 players compete in the sixth international event of the year.
Whitlock, the former European Championship winner and World Championship finalist, won 6-4 when he faced Cadby at the Melbourne Darts Masters but knows his compatriot, the former World Youth champion, will be seeking revenge.
Peter Wright, last week's Melbourne Darts Masters champion, begins his challenge for back-to-back titles against Australian qualifier Justin Thompson.
World No 1 Michael van Gerwen has drawn New Zealand's Mark Cleaver, world champion Rob Cross plays Tim Pusey, while World Matchplay winner Gary Anderson has drawn Damon Heta, who was a quarter-finalist in Melbourne.
Shanghai Darts Masters winner Michael Smith will take on Raymond Smith, while Gordon Mathers will take on five-time world champion Raymond van Barneveld.
2017 Auckland Darts Masters winner Kyle Anderson will play Barry Gardner, who is making his World Series of Darts debut.
All five of the previous World Series of Darts events have had a different champion.
2018 Brisbane Darts Masters - First round draw
Peter Wright (1) v Justin Thompson
Michael Smith v Raymond Smith
Rob Cross (4) v Tim Pusey
Simon Whitlock v Corey Cadby
Michael van Gerwen (2) v Mark Cleaver
Kyle Anderson v Barry Gardner
Gary Anderson (3) v Damon Heta
Raymond van Barneveld v Gordon Mathers
Best of 11 legs